Correction: Gephyrin-Independent GABAAR Mobility and Clustering during Plasticity
نویسندگان
چکیده
منابع مشابه
Gephyrin-Independent GABAAR Mobility and Clustering during Plasticity
The activity-dependent modulation of GABA-A receptor (GABA(A)R) clustering at synapses controls inhibitory synaptic transmission. Several lines of evidence suggest that gephyrin, an inhibitory synaptic scaffold protein, is a critical factor in the regulation of GABA(A)R clustering during inhibitory synaptic plasticity induced by neuronal excitation. In this study, we tested this hypothesis by s...
متن کاملGephyrin oligomerization controls GlyR mobility and synaptic clustering.
High local concentrations of glycine receptors (GlyRs) at inhibitory postsynaptic sites are achieved through their binding to the scaffold protein gephyrin. The N- and C-terminal domains of gephyrin are believed to trimerize and dimerize, respectively, thus contributing to the formation of submembranous gephyrin clusters at synapses. GlyRs are associated with gephyrin also at extrasynaptic loca...
متن کاملGABAAR Plasticity during Pregnancy: Relevance to Postpartum Depression
Fluctuating neurosteroid levels over the ovarian cycle modulate neuronal excitability through effects on GABA(A) receptors (GABA(A)Rs). The large increase in progesterone-derived neurosteroids during pregnancy and their precipitous decline at parturition may have considerable effects on GABA(A)Rs during pregnancy and postpartum. Here we show a significant decrease in tonic and phasic inhibition...
متن کاملPalmitoylation of Gephyrin Controls Receptor Clustering and Plasticity of GABAergic Synapses
Postsynaptic scaffolding proteins regulate coordinated neurotransmission by anchoring and clustering receptors and adhesion molecules. Gephyrin is the major instructive molecule at inhibitory synapses, where it clusters glycine as well as major subsets of GABA type A receptors (GABAARs). Here, we identified palmitoylation of gephyrin as an important mechanism of strengthening GABAergic synaptic...
متن کاملGephyrin Oligomerization Is Required for GlyR Clustering
Untethered transmembrane proteins diffuse rapidly in the plasma membrane. To ensure reliable synaptic transmission, neurotransmitter receptors are held at postsynaptic sites adjacent to presynaptic terminals by interactions with scaffolding proteins that link the receptors to the cytoskeleton. Modification of these interactions can alter the number of receptors at postsynaptic sites and thus mo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/annotation/d186036a-da60-47d1-8e3c-7e225a3539ae